Gender Medicine: The Journal for the Study of Sex & Gender Differences
Volume 8, Issue 6 , Pages 343-354, December 2011

Evidence That the G Protein–Coupled Membrane Receptor GPR30 Contributes to the Cardiovascular Actions of Estrogen

  • Sarah H. Lindsey, PhD

      Affiliations

    • Corresponding Author InformationAddress correspondence to: Sarah H. Lindsey, PhD, Hypertension and Vascular Research Center, Wake Forest School of Medicine, Hanes Building, 6th Floor, Medical Center Boulevard, Winston-Salem, NC 27157-1032
    • ,
  • Mark C. Chappell, PhD, FAHA

Hypertension and Vascular Research Center, Wake Forest School of Medicine, Winston-Salem, North Carolina

Accepted 26 October 2011.

Abstract 

Although female protection from cardiovascular diseases declines with the fall in circulating sex hormones experienced during menopause, clinical trials in older women fail to demonstrate beneficial effects for hormone replacement therapy. The recent discovery of GPR30, a membrane-bound estrogen receptor that is structurally and functionally unique from the steroid receptors ERα and ERβ, has unveiled additional signaling pathways by which estrogen may influence cardiovascular health. This review takes an organ-based approach to assess the expression and function of GPR30 in the cardiovascular system. We concluded that although the current literature does suggest a cardiovascular role for GPR30, additional exploration is necessary to fully elucidate the estrogenic actions mediated by this novel receptor.

Key words:  blood pressure , cardiovascular , estrogen receptors , GPR30 , renin-angiotensin-aldosterone system

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PII: S1550-8579(11)00223-3

doi:10.1016/j.genm.2011.10.004

Gender Medicine: The Journal for the Study of Sex & Gender Differences
Volume 8, Issue 6 , Pages 343-354, December 2011

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